Shared and Distinct Mechanisms of Skeletal muscle atrophy: A narrative review

Dylan Wilburn, Ahmed Ismaeel, Steven Machek, Emma Fletcher, Panagiotis Koutakis

Research output: Contribution to journalArticlepeer-review


Maintenance of skeletal muscle mass and function is an incredibly nuanced balance of  anabolism  and  catabolism  that can become distorted within different pathological conditions. In this paper we intend to discuss the distinct  intracellular signaling  events that regulate muscle protein atrophy for a given clinical occurrence. Aside from the common outcome of muscle deterioration, several conditions have at least one or more distinct mechanisms that creates unique intracellular environments that facilitate muscle loss. The subtle individuality to each of these given pathologies can provide both researchers and clinicians with specific targets of interest to further identify and increase the efficacy of medical treatments and interventions.
Original languageAmerican English
JournalAgeing Research Reviews
StatePublished - Nov 2021
Externally publishedYes


  • Kinesiology

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